TY - JOUR
KW - Humans
KW - Double-Blind Method
KW - Randomised Controlled Trials
KW - Treatment Outcome
KW - Single-Blind Method
KW - Research Design
KW - Risk Assessment
KW - Time Factors
KW - Reproducibility of Results
KW - Evidence-Based Medicine
KW - Comprehension
KW - Random Allocation
KW - Reading
AU - Zoungas Sophia
AU - Webster A.
AU - Jun M.
AU - Perkovic Vlado
AB - <p>
Proper evaluation of up-to-date clinical evidence is essential for the provision of optimal patient care. Randomized controlled trials (RCTs) are the ideal study type to investigate the benefit or harm of an intervention, such as a drug therapy. RCTs aims to avoid biased assessment of clinical interventions through the even distribution of both known and unknown factors that may influence outcomes. However, not all RCTs are well designed, conducted or reported. As such, the clinician needs to critically appraise RCTs in order to determine their strengths and weaknesses. This paper aims to explain how to approach critical appraisal, by highlighting and illustrating important questions that help determine the reliability of results from randomized trials.
</p>

AD - The George Institute for International Health, The University of Sydney, PO Box 201, Missenden Road, Sydney, NSW 2050, Australia.
AN - 20470272
BT - Nephrology (Carlton)
ET - 2010/05/18
LA - eng
M1 - 2
N1 - Jun, MinZoungas, SophiaPerkovic, VladoWebster, Angela CResearch Support, Non-U.S. Gov'tAustraliaNephrology (Carlton, Vic.)Nephrology (Carlton). 2010 Mar;15(2):153-7.
N2 - <p>
Proper evaluation of up-to-date clinical evidence is essential for the provision of optimal patient care. Randomized controlled trials (RCTs) are the ideal study type to investigate the benefit or harm of an intervention, such as a drug therapy. RCTs aims to avoid biased assessment of clinical interventions through the even distribution of both known and unknown factors that may influence outcomes. However, not all RCTs are well designed, conducted or reported. As such, the clinician needs to critically appraise RCTs in order to determine their strengths and weaknesses. This paper aims to explain how to approach critical appraisal, by highlighting and illustrating important questions that help determine the reliability of results from randomized trials.
</p>

PY - 2010
SN - 1440-1797 (Electronic)1320-5358 (Linking)
SP - 153
EP - 7
T2 - Nephrology (Carlton)
TI - How to read a report of a randomized controlled trial
VL - 15
ER -