01732nas a2200157   4500000000100000008004100001260001700042100001500059700001100074700001400085700001900099245013100118300001200249490000600261520130700267       2011                            d  c-484123281071 aLV Jicheng1 aJun M.1 aJardine M1 aPerkovic Vlado00aManaging cardiovascular risk in people with chronic kidney disease: a review of the evidence from randomized controlled trials  a265-2780 v23 a<p>
Cardiovascular disease is the leading cause of death and morbidity in people with chronic kidney disease (CKD) making measures to modify cardiovascular risk a clinical priority. The relationship between risk factors and cardiovascular outcomes is often substantially different in people with CKD compared with the general population, leading to uncertainty around pathophysiological mechanisms and the validity of generalizations from the general population. Furthermore, published reports of subgroup analyses from clinical trials have suggested that a range of interventions may have different effects in people with kidney disease compared with those with normal kidney function. There is a relative scarcity of randomized controlled trials (RCTs) conducted in CKD populations, and most such trials are small and underpowered. As a result, evidence to support cardiovascular risk modification measures for people with CKD is largely derived from small trials and post hoc analyses of RCTs conducted in the general population. In this review, we examine the available RCT evidence on interventions aimed at preventing cardiovascular events in people with kidney disease to identify beneficial treatments as well as current gaps in knowledge that should be a priority for future research.
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