@article{22596,
  author = {Liu Y. and Atkins E. and Guo X. and Lin K. and Li H. and Chen J. and Zhou Y. and Tan N. and Ran P. and Yang J. and Wu D. and Chen S. and Duan C. and Chen P.},
  title = {Preprocedural High-Sensitivity C-Reactive Protein Predicts Contrast-Induced Nephropathy and Long-Term Outcome After Coronary Angiography},
  abstract = {<p>
We investigated whether high-sensitivity C-reactive protein (hsCRP) levels were associated with contrast-induced nephropathy (CIN) and long-term mortality after coronary angiography (CAG). Patients (N = 2133) undergoing CAG with preprocedural hsCRP were consecutively enrolled. High-sensitivity C-reactive protein was measured before angiography. Median follow-up was 2.3 years. The overall incidence of CIN was 2.77% (59 of 2133). There was a positive trend of hsCRP quartiles (Q) with rates of CIN: 0.9% for Q1 (&lt;1.6 mg/L), 0.9% for Q2 (1.6-3.9 mg/L), 2.4% for Q3 (4.0-11.3mg/L), and 6.8% for Q4 (&gt;11.3 mg/L; P &lt; .05). The receiver operating characteristic (ROC) analysis showed that the cutoff point of hsCRP was 7.3 mg/L for predicting CIN with a 72.7% sensitivity and a 67.0% specificity (area under the curve [AUC] = 0.742, 95% confidence interval [CI] 0.672-0.810; P &lt; .05). The predictive value of hsCRP was similar to the Mehran score for CIN (AUChsCRP = 0.742 vs AUCMehran = 0.801; P = .228). After adjustment for other potential risk factors, hsCRP &gt;7.3 mg/L still was an independent predictor of CIN (odds ratio [OR] = 2.83, 95% CI: 1.44-5.58; P = .003). Furthermore, hsCRP &gt;7.3 mg/L was associated with higher mortality (OR = 2.04, 95% CI: 1.30-3.19; P = .002).
</p>
},
  year = {2016},
  journal = {Angiology},
  edition = {2016/11/05},
  isbn = {1940-1574 (Electronic)<br/>0003-3197 (Linking)},
  note = {Guo, Xiao-Sheng<br/>Lin, Kai-Yang<br/>Li, Hua-Long<br/>Chen, Ji-Yan<br/>Zhou, Ying-Ling<br/>Liu, Yong<br/>Tan, Ning<br/>Atkins, Emily R<br/>Ran, Peng<br/>Yang, Jun-Qing<br/>Wu, Deng-Xuan<br/>Chen, Shi-Qun<br/>Duan, Chong-Yang<br/>Chen, Ping-Yan<br/>United States<br/>Angiology. 2016 Oct 25. pii: 0003319716674623.},
  language = {Eng},
}